What is the formation process of kidney stones?
1. Harmful substances such as oxalate, uric acid, and phosphate in urine become overly saturated, readily forming urinary crystals.
2. Recurrent urinary crystallization can lead to the formation of calcification spots (renal calcification spots). Continuous accumulation of crystals on these spots results in small stones adhering to the renal inner wall.
3. These small stones gradually grow and develop into larger kidney stones.
What Problems Can Oxalate Degradation Enzyme Solve?
Medical Field
Prevention and treatment of kidney stones: Oxalate degradation enzyme can effectively degrade oxalate in the human gastrointestinal tract, significantly reducing the amount of oxalate available for absorption. This reduces oxalate salts in urine from the source, lowering the risk of kidney stone formation and recurrence. For example, reloxaliase, a recombinant oxalate decarboxylase from Bacillus subtilis, has been clinically proven to safely and effectively reduce urinary oxalate levels in patients with enteric hyperoxaluria.
-Treatment of oxalate-related diseases: Oxalate degradation enzyme can be used to treat or prevent conditions such as hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate nephrolithiasis (urolithiasis), vulvodynia, oxalosis associated with end-stage kidneys, cardiac conduction disorders, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, patients who have undergone gastrointestinal surgery and bariatric surgery (obesity surgery), and/or patients already receiving antibiotic therapy.
Food Field
Production of low-oxalate foods: Oxalate degradation enzyme can reduce oxalate content in food, producing low-oxalate foods and beverages. This helps people manage oxalate-related health conditions and provides healthier dietary options.
– **Improving food nutritional value**: Oxalate is an antinutrient that binds with calcium and other minerals to form insoluble compounds, hindering mineral absorption. Oxalate degradation enzyme breaks down oxalate, enhancing the bioavailability of calcium and other minerals in food.
Agricultural Field
Soil improvement: Oxalate degradation enzyme can degrade oxalate in soil, reducing its content and improving soil fertility for healthier plant growth.
Plant protection: Excessive oxalate accumulation in plants can hinder their development. Oxalate degradation enzyme degrades oxalate within plants, minimizing its negative impact on growth.
Industrial Field
Treatment of industrial wastewater: Oxalate degradation enzyme can process oxalate in industrial wastewater, preventing equipment corrosion and blockage, improving production efficiency, and reducing maintenance costs.
What products are related to oxalate degradation enzyme?
Nephure
TRA-16
EPHURE
Reloxaliase
Oxazyme
……